abstract：:There is a need for new materials and architectures for tissue engineering and regenerative medicine. Based upon our recent results developing novel scaffold architecture, we hypothesized that this new architecture would foster vascularization, a particular need for tissue engineering. We report on the potential of su...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Keskar V,Gandhi M,Gemeinhart EJ,Gemeinhart RA

更新日期：2009-08-01 00:00:00

abstract：:Research in regenerative medicine is developing at a significantly quick pace. Cell-based bone and cartilage replacement is an evolving therapy aiming at the treatment of patients who suffer from limb amputation, damaged tissues and various bone and cartilage-related disorders. Stem cells are undifferentiated cells wi...

journal_title：Journal of tissue engineering and regenerative medicine

authors： El Tamer MK,Reis RL

更新日期：2009-07-01 00:00:00

abstract：:Tissue-engineering strategies may be employed in the development of in vitro breast tissue models for use in testing regimens of drug therapies and vaccines. The physical and chemical interactions that occur among cells and extracellular matrix components can also be elucidated with these models to gain an understandi...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Parzel CA,Pepper ME,Burg T,Groff RE,Burg KJ

更新日期：2009-06-01 00:00:00

abstract：:Our recent clinical studies have demonstrated that autologous implantation of human cultured periosteal (hCP) sheets in combination with porous hydroxylapatite (HAp) particles at the site of periodontal bone defects strikingly facilitates tissue regeneration. To better understand how the hCP sheet functions at the imp...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Kawase T,Okuda K,Kogami H,Nakayama H,Nagata M,Nakata K,Yoshie H

更新日期：2009-03-01 00:00:00

abstract：:The aim of this work was to study the in vitro biocompatibility of glass-ceramic scaffolds based on 45S5 Bioglass, using a human osteosarcoma cell line (HOS-TE85). The highly porous scaffolds were produced by the foam replication technique. Two different types of scaffolds with different porosities were analysed. They...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Bretcanu O,Misra S,Roy I,Renghini C,Fiori F,Boccaccini AR,Salih V

更新日期：2009-02-01 00:00:00

abstract：:Adipose stem cells (ASCs) represent a cell population with great potential for tissue engineering applications. Several articles have been published showing the proliferation and differentiation potential, the markers and the wide range of potential applications of these cells. In the majority of these studies the ASC...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Rada T,Reis RL,Gomes ME

更新日期：2009-02-01 00:00:00

abstract：:In this study human bone marrow stromal cells (hBMSCs) were cultured on three-dimensional porous scaffolds of biomimetically mineralized collagen type I developed for bone engineering. Three different cell numbers were used for seeding of the nanocomposites, and the impact of the seeding density on proliferation and o...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Lode A,Bernhardt A,Gelinsky M

更新日期：2008-10-01 00:00:00

abstract：:Nanopatterned (330 nm wide channels) type I collagen films were prepared by solvent casting on poly(dimethyl siloxane) (PDMS) templates. These films were rolled into tubular constructs and crosslinked. Tubular constructs were incubated under cell culture conditions for 28 days and examined by stereomicroscopy and scan...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Zorlutuna P,Hasirci N,Hasirci V

更新日期：2008-08-01 00:00:00

abstract：:The aim of this study was to establish the potential of human periosteum-derived cells from elderly patients as a cell source for cartilage tissue engineering by optimizing culture conditions for both proliferation and differentiation. Periosteum was obtained from the tibiae of nine patients. Biopsies were prepared fo...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Jansen EJ,Emans PJ,Guldemond NA,van Rhijn LW,Welting TJ,Bulstra SK,Kuijer R

更新日期：2008-08-01 00:00:00

abstract：:Electrospinning has recently gained widespread attention as a process capable of producing nanoscale fibres that mimic native extracellular matrix. In this study, we compared the osteogenic differentiation behaviour of human adipose stem cells (ASCs) on a 3D nanofibre matrix of type I rat tail collagen (RTC) and a 2D ...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Sefcik LS,Neal RA,Kaszuba SN,Parker AM,Katz AJ,Ogle RC,Botchwey EA

更新日期：2008-06-01 00:00:00

abstract：:Elastin, a major component of vascular matrices, critically determines vascular mechanics and maintains the quiescence of smooth muscle cells (SMCs). Attempts to regenerate elastin in elastin-compromised blood vessels using tissue-engineering approaches is limited by the unavailability of elastogenic cues to upregulat...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Kothapalli CR,Ramamurthi A

更新日期：2008-03-01 00:00:00

abstract：:In clinical cases, many orthopaedists have been troubled with bone fragility, such as fractures after devitalization therapy for bone tumour, pathological fractures and metastatic tumours. The aim of this study was to determine whether loss of osteogenic capacity of devitalized autologous bones can be rescued using cu...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Tohma Y,Ohgushi H,Morishita T,Dohi Y,Tadokoro M,Tanaka Y,Takakura Y

更新日期：2008-01-01 00:00:00

abstract：:Nerve guides are currently being fabricated by blending a variety of biomaterials with different proteins. Adding proteins, which can support nerve repair and regeneration, optimizes the biological properties of a nerve guide. In our study we have blended glial cell line-derived nerve growth factor (GDNF) and laminin ...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Patel M,Mao L,Wu B,Vandevord PJ

更新日期：2007-09-01 00:00:00

abstract：:Bone marrow (BM) multipotent mesenchymal stromal cells (MSCs) present with multipotent differentiation potential and immunomodulatory properties. As an alternative to bone marrow, we have examined fetal membranes, amnion and chorion, of term human placenta as a potential source of multipotent MSCs. Here we show that a...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Soncini M,Vertua E,Gibelli L,Zorzi F,Denegri M,Albertini A,Wengler GS,Parolini O

更新日期：2007-07-01 00:00:00

abstract：:Microstructure in terms of hierarchical assembly exists widely in mineralized biomaterials, fulfilling an important role in setting up their outstanding properties. The purpose of this study was to investigate the hierarchical assembly of enamel structure and functions, which are related to the unique characteristics ...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Cui FZ,Ge J

更新日期：2007-05-01 00:00:00

abstract：:New injectable acrylic formulations have been prepared to be applied in restoration processes for intervertebral disks (IVDs). The solid phase of the formulations is composed of poly(methyl methacrylate) (PMMA), incorporating in some cases chondroitin sulphate (CS) as a regenerative bioactive molecule, whereas the liq...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Larraz E,Elvira C,Fernández M,Parra J,Collía F,López-Bravo A,Román JS

更新日期：2007-03-01 00:00:00

abstract：:Bone-like apatite is a carbonated hydroxyapatite with a small crystallite and low crystallinity. The formation of a layer consisting of bone-like apatite is an essential condition for bioactive materials to achieve direct bonding with living bone. A bone-like apatite layer can be formed on the surface of organic subst...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Ohtsuki C,Kamitakahara M,Miyazaki T

更新日期：2007-01-01 00:00:00